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37. New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity -- YEAMAN et al. 79 (1): 73 -- Physiological Reviews
- physrev.physiology.org
- Focal adhesion kinase is a tyrosine kinase that localizes to focal adhesions through a carboxy-terminal focal adhesion targeting (FAT) domain (137) that partially overlaps with a paxillin-binding motif (138). ... Overexpression of a dominant-negative construct containing the FAT domain results in displacement of FAK from focal adhesions and a concomitant decrease in tyrosine phosphorylation of FAK, paxillin, and tensin (111). However, these cells still assemble focal adhesions, although the rate at which they do so is reduced. Furthermore, cells lacking FAK are able to form normal focal adhesions (166). ... These events increase contractility and, together with integrin binding to ECM proteins, appear to be required for formation of focal adhesions and changes in cell morphology (43, 151). ...
- Focal adhesions, contractility, and signaling. ...
- Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. ...
- Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. ...
38. Cancer Spectrum: Brinkman et al., pp. 112-120.
- jncicancerspectrum.oupjournals.org
- p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. ...
- Requirements for localization of p130CAS to focal adhesions. ...
- Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions. ...
- The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions. ...
39. Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes -- Clark et al. 130 (12): 2611 -- Development
- dev.biologists.org
- In vertebrate cells, PINCH and ILK appear to be mutually dependent on each other for their localization to integrin-rich focal adhesions (Zhang et al. ...
- Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. ...
- Integrin-linked kinase (ilk) binding to paxillin ld1 motif regulates ilk localization to focal adhesions. ...
40. Both Protein Activation and Gene Expression Are Involved in Early Vascular Tube Formation in Vitro -- Grove et al. 8 (9): 3019 -- Clinical Cancer Research
- clincancerres.aacrjournals.org
- Overexpression of caldesmon in human fibroblasts inhibits cell contractility and interferes with Rho A-mediated formation of stress fibers and focal adhesions (13). ...
- Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. ...
41. Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells -- Demir et al. 19 (1): 21 -- Human Reproduction
- humrep.oupjournals.org
- Fincham VJ and Frame MC (1998) The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. ...
- Frame MC, Fincham VJ, Carragher NO and Wyke JA (2002) v-Srcs hold over actin and cell adhesions. ...
42. Ca2+-independent myosin II phosphorylation and contraction in chicken embryo fibroblasts -- Kolodney et al. 515 (1): 87 -- The Journal of Physiology Online
- jp.physoc.org
- Formation of actin stress fibrils and focal adhesions enhanced by Rho-kinase. ...
- Rho-stimulated contractility drives the formation of stress fibres and focal adhesions. ...
43. Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells -- Kaempchen et al. 12 (11): 1211 -- Human Molecular Genetics
- hmg.oupjournals.org
- (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. ...
- (2002) Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. ...
44. Spatial and temporal patterns of ERK signaling during mouse embryogenesis -- Corson et al. 130 (19): 4527 -- Development
- dev.biologists.org
- Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src. ...
45. Endometriosis
- www.drdaiter.com
- Reduction of Postoperative Adhesions (Scar) .
- " When the infertility surgeon recreates a pelvic organ, opens a previously blocked fallopian tube, removes abnormal structures from within the uterine cavity, ablates endometriosis, or lyses existing pelvic adhesions the restoration of normal anatomy and function often depends on minimizing scar tissue secondary to the surgery. ...
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